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KMID : 0613320090150020104
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Journal of the Korean Bone and Joint Tumor Soceity
2009 Volume.15 No. 2 p.104 ~ p.110
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Outcome of Extraskeletal Osteosarcoma; Case-control Study with High Grade Soft Tissue Sarcoma
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Cho Wan-Hyeong
Lee Soo-Yong
Song Won-Seok
Kong Chang-Bae
Won Ho-Hyun
Hong Youn-Seok
Jeon Dae-Geun
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Abstract
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Purpose: Compared to soft tissue sarcoma, the relative risk of extraskeletal osteosarcoma is still not clear. The purpose of this study is to identify the difference in survival and local recurrence rate between two soft tissue sarcomas.
Materials and Methods : Twelve patients with pathologically confirmed extraskeletal osteosarcoma were analysed. For retrospective matched case-control study, we selected 72 patients who were confirmed as high grade soft tissue sarcoma and had similar tumor location, tumor size and age to extraskeletal osteosarcoma.
Results: Median age was 50 years old. Five cases were located in upper extremity, four in the buttocks, three in the lower extremity. Overall survival rate of extraskeletal osteosarcoma group and high grade soft tissue sarcoma group at 5 years were 52% and 55%. There is no significant difference (p=0.8). Local recurrence rate and metastasis rate were 58%, 67% in extraskeletal osteosarcoma group and 36%, 51% in soft tissue sarcoma group, which were not stastistically significant(p=0.2, p=0.4).
Conclusion: Extraskeletal osteosarcoma have similar local recurrence, metastasis and survival rate compare to high grade soft tissue sarcoma. The number of patients of this study were too small to identify outcome of extraskeletal osteosarcoma. Further multi-institutional study should be attempted.
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KEYWORD
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Extraskeletal osteosarcoma, Outcome
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